Butanol-extractable iodine of serum.
نویسندگان
چکیده
It has been demonstrated chemically that the iodine bound to proteins of the serum is predominantly composed of thyroxine (1-4). The concentration of this protein-bound or serum precipitable iodine (SPI) appears to be closely correlated with the activity of the thyroid gland (5-7). It is probably the most precise clinical criterion of such activity that has yet been extensively employed. It is, therefore, generally conceded that SPI ordinarily represents circulating thyroid hormone. In studies of medically treated hyperthyroid patients, however, a number of values for SPI proved unexpectedly high in comparison with other measures of thyroid activity (5, 7). Danowski and associates (8-10) reported that SPI of normal individuals and pregnant women rose after the administration of potassium iodide. It had also been discovered that certain iodine-containing compounds commonly used for diagnostic and therapeutic purposes formed combinations with the proteins of the serum and therefore were measured with SPI (11). For these reasons it seemed desirable to examine more closely the nature of SPI and to find a more specific measure of circulating thyroid hormone. Taurog and Chaikoff (4) utilized N-butanol to extract thyroxine-like compounds from serum. This solvent, originally employed by Leland and Foster (12), can be freed from diiodotyrosine and inorganic iodine by means of an alkaline reagent suggested by Blau (13). Taurog and Chaikoff (4) found that 73 to 93 per cent of the iodine of normal plasma behaved like thyroxine inasmuch as it remained in butanol extracts after these had been washed with Blau's reagent. Danowski and associates (8-10) compared the iodine extracted by butanol with SPI in the sera of normal individuals, pregnant women, and persons taking potassium iodide. The mean value for iodine extraced by butanol in the sera from 23 healthy
منابع مشابه
A simplified method for butanol-extractable iodine and butanol-insoluble iodine.
A simplified method is presented for the determination of butanol-extractable iodine (BEI). The results compare favorably with the original method as described by Man et al. Also available, as part of the procedure for BEI, is a direct chemical determination for butanol-insoluble iodine (Bli) from the same specimen of serum. Heretofore, nonbutanol-extractable iodine has been studied only by mea...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 30 5 شماره
صفحات -
تاریخ انتشار 1951